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KMID : 1039620140040040328
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Korean Journal of Family Practice
2014 Volume.4 No. 4 p.328 ~ p.334
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High Dose Intravenous Vitamin C during Radiotherapy Impact on Breast Cancer Recurrence
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Choi Jong-Soon
Kim Jeong-Hwan
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Abstract
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Background: Very high incidence of breast cancer is increasing every year. After breast cancer surgery and radiotherapy for about 3 years, adjuvant therapy for the prevention of recurrence is very important, to help prevent recurrence in the adjuvant treatment studies are lacking on. In this study, patients with breast cancer receiving radiotherapy and high dose of vitamin C administered intravenously to help ensure reduction in recurrence rate were investigated.
Methods: We retrospective reviewed 216 women patients with breast cancer, without distant metastasis (M=0 at the tumor
node metastasis stage) and who were starting postoperative radiotherapy by Kosin University Gospel Hospital in Busan from January 2006 to December 2010. Th e experimental group of 72 patients with radiotherapy and high dose of vitamin C (1 g/kg) intravenously twice a week were administered three months, another 144 patients of the control group without vitamin therapy, but radiotherapy was performed. Every year after surgery, both groups were performed several tests, performed by chi-square test compared the 3-year recurrence rate.
Results: Intravenous administration of vitamin C in 72 people within three years of local recurrence and distant metastasis in women who recurred in 5 patients (recurrence rate, 6.94%), 144 people in the control group of 27 women recurred patients (recurrence rate, 18.75%) as shown vitamin C intravenously treated group compared with the control group was signifi cantly lower recurrence rate (P=0.028).
Conclusion: Women with breast cancer receiving radiotherapy, high dose intravenous vitamin C for the prevention of recurrence as adjuvant therapy can be considered to be helpful.
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KEYWORD
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Breast Neoplasms, Radiotherapy, High Dose Vitamin C, Recurre
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