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KMID : 1039620140040040335
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Korean Journal of Family Practice
2014 Volume.4 No. 4 p.335 ~ p.340
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Risk Factors of Cerebral Small-Vessel Disease in Asymptomatic Adults
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Na Yeoun-Ja
Um Mi-Ra
Kim Joo-Il
Kong Mi-Hee
Kim Hyeon-Ju
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Abstract
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Background: As an indicator of cerebral small-vessel disease (CSVD), leukoaraiosis and lacunar infarct are known to possible to progress the chronic disease such as cerebral infarct or dementia. Th ese lesions have observed incidentally on brain computed tomography or magnetic resonance imaging (MRI) for health check without neurologic symptom or sign. We investigated the risk factors of these lesions of asymptomatic adults.
Methods: Two hundred and ninety-four individuals who underwent the brain MRI in one health promotion center from 1st April 2009 to 30th June 2013 were analyzed based on previous medical history, current medication, age, gender, body mass index, blood pressure, blood tests, and behavioral habits including alcohol drinking, smoking, and exercise.
Results: CSVD group is 118 individuals (40.1%), 65 men and 53 women and there are no differences of prevalence between gender. Average age of CSVD group is 57.35±8.35 years, higher than 51.62±10.59 years of normal group (P<0.01). The prevalence of CSVD was increased by age increase when we classified into 3 age group of <40 years, 40?59 years and ≥60 years (P for trend<0.01). Among risk factors of cardiovascular disease such as age and sex, hypertension, diabetes mellitus, and behavioral habits, only age and hypertension were shown statistically meaningful result. Furthermore, multivariate regression analysis adjusted by age, gender and other risk factors was shown the association of the age, hypertension with CSVD.
Conclusion: This study suggests that hypertension were related with CSVD identified on MRI in asymptomatic adults, the prevalence of CSVD was increased as age increase.
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KEYWORD
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Cerebral Small Vessel Disease, Leukoaraiosis, Stroke, Lacunar, Risk Factors
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