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KMID : 1039620150050000097
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Korean Journal of Family Practice
2015 Volume.5 No. 0 p.97 ~ p.101
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The sensitivity and specificity of diagnostic tools of clostridium difficile infection; Single Center Study
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Eo Yun-Ho
Chung Yun-Hee
Kang In-Young
Park Kwang-Gyu
Nam-Ju Ahn
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Abstract
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Background : Clostridium difficile infection (CDI) is a common cause of diarrhea in hospitalized patients. The global incidence and severity of CDI appears to be increasing, resulting in substantial healthcare costs. This study evaluatedvarious methods for detecting CDIs in a local hospital and considered effective and efficient methods for testing patients in domestic medical settings.
Method : In this retrospective study of patients with diarrhea who were admitted during or after antibiotic use, we collected results of 583 C. difficile toxin A and B tests performed during a one-year period from January to December 2013; these results were analyzed and compared to C. difficile culture and sigmoidoscopy data.
Result : Based on sigmoidoscopy results, the sensitivity/specificity of C. difficile toxin A and B tests and C. difficile culture were 68%/86.9% and 80%/78%, respectively. The sensitivity and specificity of sigmoidoscopy based on C. difficile culture results were 40.0% and 95.0%, respectively.
Conclusion : Repeated C. difficile toxin A and B testing may increase the test sensitivity. In elderly and comorbid patients, treatment may be started before test results are available. In cases of mild to moderate CDI, sigmoidoscopy is preferred for early detection and treatment.
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KEYWORD
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Clostridium difficile infection, C, difficile toxin A and B, Sigmoidoscopy, Sensitivity
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