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KMID : 1039620150050000150
Korean Journal of Family Practice
2015 Volume.5 No. 0 p.150 ~ p.157
Relationship between serum lipid profile and bone mineral density in Postmenopausal Korean women : The 4th(2008~2009) and 5th(2010~2011) Korea Health and Nutrition Examination Surveys(KNHANES IV & V)
Kim Ye-Seul

Kim Young-Sung
Park Young-Min
Lee Jae-Il
Abstract
Background : We determined the correlation of serum lipid concentration with bone mineral density (BMD) in postmenopausal women and investigated whether abnormal serum lipid concentration is a risk factor for osteoporosis.

Methods : We analyzed the data of 1799 postmenopausal women aged 50-70 years who participated in the Korean National Health and Nutrition Examination Survey from 2008 to 2011; 479 women had osteoporosis (the osteoporosis group); and 1320 did not (the non-osteoporosis group). We analyzed the serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). In addition, we analyzed mean BMD measured at the lumbar spine (LS), femur neck (FN), and total femur (TF). We used logistic regression analysis to calculate the odds ratios (ORs) for bone density in both the groups.

Results : The serum lipid concentration did not significantly differ between the osteoporosis and non-osteoporosis groups. In the osteoporosis group, LS BMD and TF BMD were positively correlated with TG concentration, and TN BMD was positively correlated with HDL-C concentration. The logistic regression analysis showed that; the OR for high TC concentration was greater than 1 at all the sites in the osteoporosis group. However, the ORs for other lipid concentrations were less than 1 in both the groups.

Conclusion : A correlation was observed between serum lipid concentrations and osteoporosis prevalence. However, serum lipid concentration may not be a risk factor of osteoporosis;. A prospective study, taking into account multiple factors, in a larger group will be required to draw definite conclusions.
KEYWORD
Postmenopausal women, Bone density, Osteoporosis, Cholesterol, Dyslipidemia
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