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KMID : 1039620150050000168
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Korean Journal of Family Practice
2015 Volume.5 No. 0 p.168 ~ p.172
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Relationship between C-reactive protein and QTc interval
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Kim Byung-Mu
Yang Seong-Gwan
Jun Keun-Hwa
Kim Shin-hye
Seo Min-Seok
Lee Yong-Jae
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Abstract
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Background : Chronic low-grade inflammation is a risk factor for metabolic syndrome, CVD and DM. The aim of the present study was to determine the association between C-reactive protein and QTc interval.
Methods & materials : We analyzed 328 Korean female subjects at a health promotion center of a Gangnam Severance hospital from July, 2007 to October, 2008. The standard 12-lead electrocardiogram measured the QTc interval. Multiple linear regression analysis was conducted to determine the relationship between C-reactive protein (CRP) and QTc.
Result : After adjusting for age, BMI, hypertension, diabetes, smoking, calcium, potassium, total cholesterol, and HDL cholesterol, CRP was independently and positively associated with QTc (p = 0.023) in women.
Conclusion : This study demonstrates a positive relationship between CRP and QTc interval. These findings indicate that QTc interval may be closely related with subclinical low-grade inflammation.
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KEYWORD
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QTc, CRP, inflammation, Korean women, CVD, metabolic syndrome
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