KMID : 1039620150050000195
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Korean Journal of Family Practice 2015 Volume.5 No. 0 p.195 ~ p.200
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Association between colorectal adenoma and dyslipidemia
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Kim Jeong-Eun
Park Young-Kyu Lee Kyung-Shik Cho Sung-Min Choi Young-Ah Kwack Tae-Eung Kim Bo-Seon Kim Jin-Wook Jo Eun-Bae Lee So-Hye Jung Seung-Eun Lee Seung-Hwa
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Abstract
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Background : Colorectal adenoma is a prodromal change of colorectal cancer and its detection is important in the prevention of colorectal cancer. Many studies have suggested an association between colorectal adenoma and dyslipidemia, but they have shown inconsistent results. In this study, we investigated the association between colorectal adenoma and dyslipidemia.
Methods : 620 cases of colorectal adenoma and 2006 controls with no adenoma were compared in this study. Subjects underwent colonoscopy screening by experienced gastroenterologists. Demographic data, including smoking status, were obtained using a questionnaire, and triglyceride levels, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol levels, and body mass index were measured. Statistical analysis was performed using SPSS 18.0.
Results : There were significantly higher total cholesterol and triglyceride levels in subjects with colorectal adenoma than the controls, but no difference in low-density lipoprotein cholesterol or high-density lipoprotein cholesterol levels between the two groups. After adjusting for variables including sex, age, body mass index, smoking, and alcohol intake, we found that dyslipidemia did not significantly increase the risk of colorectal adenoma. However, men with high-density lipoprotein cholesterol levels < 40 mg/dL were found to have a significantly lower risk of colorectal adenoma than men with high-density lipoprotein cholesterol levels ¡Ã40 mg/dL (odds ratio[OR], 0.60; confidence interval [CI], 0.42-0.87).
Conclusion : This study demonstrated that dyslipidemia was not significantly associated with prevalence of colorectal adenoma. However, high-density lipoprotein cholesterol levels < 40 mg/dL were associated with a decreased prevalence of colorectal adenoma in men.
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KEYWORD
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colorectal adenoma, dyslipidemia, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol
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