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KMID : 1039620150050000201
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Korean Journal of Family Practice
2015 Volume.5 No. 0 p.201 ~ p.205
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Association of Urinary Polycyclic Aromatic Hydrocarbons and Body Fat Distribution
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Jung Hyuk
Kim Kwang-Jin
Kim Mun-Taek
Park Kyung-Taek
Oh Taek-Geun
Lee Seock-Hwan
Kim Hyun-Woo
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Abstract
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Background : Polycyclic aromatic hydrocarbons (PAHs) are known carcinogens and may be obesogens. However, analysis by dual energy X-ray absorptiometry (DXA) of the relationship between PAHs and regional body fat and fat distribution has not yet been evaluated in the literature.
Methods : We performed cross-sectional analysis of 926 individuals 8-19 years of age who participated in the 2003-2006 U.S National and Nutrition Examination Survey(NHANES). We performed multivariate linear regression to analyze the association between urinary concentration of PAHs metabolites and fat measurements using DXA.
Results : DXA analysis showed that the sum of the urinary concentration of PAH metabolites was positively associated with fat measurements including the android to gynoid ratio. Adjusted mean changes of android percent fat (%) and gynoid percent fat (%) across quartiles of urinary PAHs were 0.00, 2.91, 2.12, 4.24 (P for trend < 0.001) and 0.00, 2.46, 2.27, 3.26 (P for trend < 0.001), respectively. Adjusted mean changes of android to gynoid ratio (%) across quartiles of urinary PAHs were 0.00, 2.62, 0.51, 3.80 (P for trend = 0.001).
Conclusion : Exposure to PAHs was positively associated with fat measurements in American children and adolescents. This study provides additional evidence that PAHs might be obesogens and may be associated with fat distribution. Further studies are needed to confirm these relationships.
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KEYWORD
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Polycyclic aromatic hydrocarbons, Obesity, Fat measurements, DXA, NHANES
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