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KMID : 1039620150050020095
Korean Journal of Family Practice
2015 Volume.5 No. 2 p.95 ~ p.99
Association between Helicobacter pylori Infection and the Framingham Risk Score
Kim Hoi-Kyoung

Kim Yu-Lee
Ha Kil-Yong
Lee Wan
Abstract
Background: Several studies have reported that Helicobacter pylori (H. pylori) infection is associated with cardiovascular disease, whereas other studies have shown contrary results; thus, this association remains unclear. The Framingham risk score (FRS) is a conventional clinical risk score is used to determine 10-year cardiovascular risk. The aim of our study was to confirm the association between H. pylori infection and the FRS.

Methods: This study included 1,310 healthy subjects who had visited the Busan Medical Center from January 2013 to December 2014. The subjects underwent esophagogastroduodenoscopy with the rapid urease test (CLO test) to confirm H. pylori infection and completed questionnaires about age, smoking, and medical history. Blood pressure, serum total cholesterol, and high density lipoprotein cholesterol levels were determined. The subjects were divided into the H. pylori-positive group and the H. pylori-negative group.

Results: The FRS was the highest in the H. pylori-positive group, but the difference in the scores between groups was not statistically significant (P>0.05). The subjects were divided into three risk groups on the basis of the FRS; the proportion of H. pylori infection was higher in the high-risk group than in the low-risk and intermediate-risk groups. However, the differences in proportions were not statistically significant (P>0.05). In multiple logistic regression models, a high total cholesterol level was associated with the presence of H. pylori infection (odds ratio, 1.003; 95% confidence interval, 1.001 to 1.006; P=0.043).

Conclusion: Although not statistically significant, H. pylori infection correlated with a high FRS. Moreover, this infection correlated with the cardiovascular risk factor such as a high total cholesterol level.
KEYWORD
Helicobacter pylori, Cardiovascular Disease, Risk Assessment
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