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KMID : 1039620160060010037
Korean Journal of Family Practice
2016 Volume.6 No. 1 p.37 ~ p.43
Accuracy of Capillary Cholesterol Test When Fasting in Dyslipidemic Patients or General Population: Comparison with Venous Cholesterol Test
±è¿µÁø:Kim Young-Jin
±è¼±Èñ:Kim Sun-Hee/ÃÖºÀ¼®:Choi Bong-Suk/Àå¹Ì:Jang Mi/½Å°æ¼÷:Shin Kyung-Suk/À¯º´¿í:Yoo Byung-Wook/Á¶¿ëÁø:Cho Yong-Jin/¿ÀÁ¤Àº:Oh Jung-Eun/Á¶ÁÖ¿¬:Cho Choo-Yon/È«¼ºÈ£:Hong Sung-Ho
Abstract
Background: Dyslipidemia is a strong risk factor for cardiovascular disease (CVD), which has been increasing in prevalence in South Korea, so its early diagnosis and continuous management is important. The aim of this study was to evaluate the accuracy and agreement of LipidPro portable cholesterol analyzer with respect to standard venous cholesterol testing methods.

Methods: Fasting capillary and venous cholesterol samples were collected from 96 adult patients. Fingerstick samples were immediately analyzed on a LipidPro portable analyzer, and venous samples were analyzed in a clinical laboratory. In the analysis, the following tests were included: paired t-test, linear regression analysis, percent bias, and misclassification rate.

Results: The correlation between capillary and venous samples for total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDLC), and low density lipoprotein cholesterol (LDLC) were 0.615, 0.605, 0.517, and 0.533, respectively, showing statistical significance (all P<0.05). All except TG had lower capillary mean values than venous mean values (all P<0.05). The percent bias values for TC (-13.25%), TG (21.54%), HDLC (-29.61%), and LDLC (-22.93%) were all outside of the acceptable ranges, and the misclassification rates were generally higher for higher CVD risk categories within all lipid parameters except HDLC.

Conclusion: Our findings suggest that LipidPro has weak correlation and low accuracy compared with venous cholesterol values. The results further suggest that LipidPro has several limitations that must be addressed in order to make the most appropriate clinical decisions for screening, diagnosis and management of dyslipidemia patients.
KEYWORD
Dyslipidemias, Cholesterol, Capillary Blood, Venous Blood, LipidPro
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