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KMID : 1039620160060050435
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Korean Journal of Family Practice
2016 Volume.6 No. 5 p.435 ~ p.440
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Fecal Occult Blood Test as a Screening Method for Asymptomatic Patients with Colorectal Neoplasia
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Han Kyung-Koo
Youn Chang-Ho
Koh Hae-Jin
Kim A-Sol
Kim Hyo-Min
Kim Hyun-Sook
Park Sung-Kyu
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Abstract
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Background: Colorectal cancer is one of the most common malignant tumors, and its occurrence has been increasing recently. The fecal occult blood test (FOBT) has been studied for its usefulness as a screening method of colorectal cancer. However, in Korea, adequate studies on colorectal neoplasia, including premalignant polyps, are lacking. Thus, this study focused on the usefulness of FOBT as a screening method for colorectal neoplasia.
Methods: A total of 32,813 asymptomatic adults who visited a general hospital for health screenings from 2005 to 2010 were included in the analysis. Of these, 2,991 subjects underwent both FOBT and screening colonofiberscopy (CFS). According to the CFS result, the subjects were divided into four groups: normal, tubular adenoma, advanced adenoma, and cancer. The usefulness of FOBT compared to CFS was analyzed.
Results: The rate of diagnosed colorectal cancer from positive FOBT cases was 7.9%, and this was a statistically meaningful and higher result compared to the rate of 0.6% from negative FOBT cases. Moreover, FOBT showed 22% sensitivity and 98% specificity. Multivariate logistic regression analyses revealed odds ratios of 0.368 and 6.176 in the tubular adenoma and colorectal cancer groups, respectively.
Conclusion: FOBT is a useful screening method for colorectal cancer, with appropriate sensitivity and specificity. However, it has a low value for precancerous lesions such as adenoma because of its low sensitivity for the diagnosis of all colonic neoplasms.
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KEYWORD
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Fecal Occult Blood Test, Colonofiberscopy, Colorectal Cancer, Colorectal Neoplasia
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