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KMID : 1039620160060060651
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Korean Journal of Family Practice
2016 Volume.6 No. 6 p.651 ~ p.659
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The Association of Eating and Exercise Habits, Occupation, and Working Hours with Genomic Damage in Healthy Middle-Aged Koreans
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Cho Nan-Young
Kim Kyung-Woon
Kim Seung-Jin
Kim Seon-Hee
Kim Kyoung-Kon
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Abstract
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Background: DNA damage can be measured using cytokinesis-block micronucleus cytome (CBMN-Cyt) assay. The purpose of this study was to determine the effect of eating and exercise habits, occupation, and working hours in healthy middle-aged Koreans on DNA damage parameters.
Methods: The extent of DNA damage was evaluated by the frequency of micronuclei (MNi), nucleoplasmic bridges (NPBs), and nuclear buds (NBUDs) using the CBMN-Cyt assay in 300 healthy males and females aged between 30-59 years. Details about the participants’ occupation, daily working hours, and exercising and eating habits were obtained and their relationship with the CBMN-Cyt assay parameters was analyzed.
Results: There were no significant differences in the frequencies of MNi, NPBs, and NBUDs in both sexes based on their occupations and daily working hours. Considering participants’ sex and age together, exercising habits were not associated with DNA damage parameters. However, regular intake of fried or stir-fried food items was observed to be significantly associated with an increase in the frequency of NBUDs (P=0.003).
Conclusion: In general, no significant association was observed between DNA damage parameters and the occupation, daily working hours, and exercise habits of 30-59 year-old healthy Koreans; however, regular intake of fried or stir-fried food items was associated with an increase in DNA damage.
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KEYWORD
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DNA Damage, Exercise, Occupations, Feeding Behavior
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