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KMID : 1039620160060060699
Korean Journal of Family Practice
2016 Volume.6 No. 6 p.699 ~ p.702
Effect of Serum Vitamin D Level on Nicotine Metabolism to Cotinine in Korean Adults: 5th Korea National Health and Nutrition Examination Survey, 2011
Lee Je-Won

Kim Eun-Kyung
Kim Jung-Hun
Park Min-Gyu
Lee Jae-Sung
Lee Jin-Hee
Cho Chung-Hwan
Park Dong-Ju
Abstract
Background: Nearly 70%-80% of nicotine, a carcinogen inhaled during smoking, in the human body is converted to cotinine, a stable compound. The rest is converted to other carcinogens such as nitrosamines. Many studies have reported the effectiveness of vitamin D in preventing smoking-related cancer. In this study, we have investigated the influence of vitamin D on nicotine metabolism to cotinine, which is a competitive inhibitor of nitrosamine.

Methods: We used the data from the 5th Korea National Health and Nutrition Examination Survey, 2011. The Korean adults included in our analysis were grouped by current smoking status and quantity of smoking. We measured vitamin D levels by the serum 25(OH)D test and cotinine levels by a urine test.

Results: Vitamin D did not have any effect on nicotine metabolism to cotinine in any study group.

Conclusion: Further studies are needed to investigate the relationship between vitamin D and smoking-related cancer, and investigate the appropriate administration of vitamin D as a nutritional treatment.
KEYWORD
Vitamin D, Cotinine, Nicotine, Korea National Health and Nutrition Examination Survey
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