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KMID : 1039620170070030388
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Korean Journal of Family Practice
2017 Volume.7 No. 3 p.388 ~ p.393
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The Association between Benign Prostate Enlargement and Nonalcoholic Fatty Liver Disease
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Koh Young-Ho
Lee Dong-A
Song Min-Gou
Kim Jae-Bin
Noh Bo-Reum
Lee Jung-Hwan
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Abstract
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Background: Metabolic syndrome plays a potential role in the development of benign prostate enlargement. Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic component of metabolic syndrome. In this study, we evaluated the association between benign prostate enlargement and NAFLD in men who underwent a prostate health check-up in our center.
Methods: A total of 405 men who underwent transrectal ultrasonography at a health promotion center in Suwon from January 2011 to December 2014 were included in this retrospective study. Body measurements (height, weight, waist circumference, and body mass index), blood pressure, and blood tests (fasting glucose, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase) were obtained. Prostate volume was measured using transrectal ultrasonography and benign prostate enlargement was defined as prostate volume over 20 mL. All participants were separated into two groups, with or without NAFLD, using blinded abdominal ultrasonography.
Results: The prevalence of benign prostate enlargement and NAFLD was 50.4% (n=204) and 46.9% (n=190), respectively. The benign prostate enlargement group showed significantly greater age, weight, waist circumference, body mass index, AST, ALT, and prevalence of NAFLD (P<0.005). In multiple logistic regression analysis, the NAFLD group showed significantly higher prostate volumes than the group without NAFLD (odds ratio, 1.065; 95% confidence interval, 1.015?1.117; P=0.010).
Conclusion: Multiple logistic regression revealed independent correlations between NAFLD and prostate volume in this study. This suggests that increases in prostate volume and NAFLD are linked to a common etiopathogenic mechanism.
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KEYWORD
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Benign Prostate Enlargement, Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome, Ultrasonography
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