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KMID : 1039620170070030400
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Korean Journal of Family Practice
2017 Volume.7 No. 3 p.400 ~ p.404
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A Correlation between Secondhand Smoking and Prevalence of Helicobacter pylori Infection
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Park Jong-Myeng
Kim Hyun-Woo
Lee Seock-Hwan
Park Do-Kyung
Park Eun-Sook
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Abstract
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Background: Helicobacter pylori infection and smoking are known as risk factors for peptic ulcer disease and gastric cancer. We performed a crosssectional analysis of the National Health and Nutrition Examination Survey (NHANES; 1999?2000) data and evaluated the relationship between secondhand smoking and the prevalence of H. pylori infection.
Methods: We analyzed 3,335 nonsmokers among the civilian, noninstitutionalized U.S. population in the 1999?2000 NHANES data, who were more than 20 years of age, and had provided data through standard questionnaires and serum cotinine levels. We defined nonsmokers as those having a serum cotinine level <10 ng/mL. H. pylori infection was evaluated with an immunoglobulin G enzyme-linked immunosorbent assay test. We analyzed the distribution of H. pylori infection according to the following variables: demographics, vitamin C intake, number of drinks of alcohol per year, cigarette smoking status, time since quitting, pack-years, and serum cotinine levels.
Results: Secondhand smoking, as measured by increased serum cotinine levels, was associated with an increased prevalence of H. pylori infection (prevalence odds ratio=2.5; 95% confidence interval, 1.4?4.5). There was evidence of a dose-response correlation between H. pylori and secondhand smoking, as indicated by the serum cotinine level.
Conclusion: Secondhand smoking is associated with the prevalence of H. pylori infection.
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KEYWORD
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Secondhand Smoking, Helicobacter pylori, Serum Cotinine Levels
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