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KMID : 1039620170070030424
Korean Journal of Family Practice
2017 Volume.7 No. 3 p.424 ~ p.430
Association of the Serum Homocysteine Levels and Nonalcoholic Fatty Liver Disease
Kim Ji-Hyun

Youn Chang-Ho
Koh Hae-Jin
Kim A-Sol
Kim Hyo-Min
Kim Hyun-Sook
Kim Min-Sun
Abstract
Background: Studies of serum homocysteine levels in patients with non-alcoholic fatty liver disease (NAFLD) have resulted in inconsistent results. Our aim was to determine the association of serum homocysteine levels with NAFLD.

Methods: The study subjects include 4,134 healthy women who visited Kyungpook National University Hospital for health check-ups from January 2013 to February 2014. Patients whose daily alcohol consumption was >20 g or who had liver disease from a different cause were excluded. NAFLD was defined as the presence of a bright liver on ultrasound imaging not caused by other liver disease. Participants were divided into four quartiles (Q1, Q2, Q3, and Q4) according to their serum homocysteine levels (¡Â6.2 ¥ìmol/L, 6.3?7.5 ¥ìmol/L, 7.6?9.1 ¥ìmol/L, and ¡Ã9.2 ¥ìmol/L), and the incidence of NAFLD was assessed.

Results: Elevated serum homocysteine levels were associated with an increased incidence of NAFLD (P<0.001, P for trend <0.001). The odds ratio (OR) of NAFLD was 1.246 (95% confidence interval [CI]=1.035?1.502, P=0.020) among the Q3 participants and 1.590 (95% CI=1.325?1.908, P<0.001) among the Q4 participants, compared to that among Q1 participants. After adjusting for various covariates, the odds ratios of Q3 and Q4, compared to that of Q1, were significant (OR=1.314, 95% CI=1.077?1.605, P=0.007 in Q3; OR=1.478, 95% CI=1.214?1.798, P<0.001 in Q4).

Conclusion: Serum homocysteine level had a statistically significant positive correlation with the incidence of NAFLD. NAFLD is highly affected by obesity and further studies to investigate serum homocysteine as a marker of NAFLD among non-obese patients are needed.
KEYWORD
Female, Non-Alcoholic Fatty Liver Disease, Homocysteine, Obesity
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