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KMID : 1039620170070050781
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Korean Journal of Family Practice
2017 Volume.7 No. 5 p.781 ~ p.785
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Uncarboxyolated Osteocalcin Inversely Correlated with Total Testosteorone Level in Elderly Man
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Na Kyung-Min
Jung Suk-In
Kim Bom-Taeck
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Abstract
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Background: Osteocalcin is the bone formation marker released by osteoblasts. Evidence supports the association between osteocalcin and testosterone synthesis. However, conflicting reports exist regarding the relationship between undercarboxylated osteocalcin (ucOC) and testosterone level. These were small-scale studies or studies on comorbidities in males. This study aimed to investigate the association between UCOC and testosterone level in males.
Methods: This was a cross-sectional and cohort study that included 510 healthy men aged 40?70 years who had no comorbidities. Levels of total testosterone, sex hormone-binding globulin, osteocalcin, UCOC; bone density; other laboratory parameters; and lifestyle characteristics were measured. Data were grouped according to age and testosterone level of 〈3.5 ng/mL. The relationship between UCOC and testosterone levels was analyzed and adjusted for age, bone mineral density (BMD), and factors that affect testosterone level.
Results: The UCOC level in the subjects aged 〉61 years who had low testosterone levels was 3.79 ng/mL, higher than that in the general (1.62 ng/mL) and 40- to 60-year age groups (1.37 ng/mL), with an analysis of covariance P-value of 0.04. However, no association was found between UCOC and testosterone levels in the age groups with normal testosterone levels.
Conclusion: This study suggests that UCOC has an inverse correlation with testosterone level in elderly Korean men. Measurement of UCOC level is useful in hypogonadism studies in males with BMD data.
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KEYWORD
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Testosterone, Osteocalcin, Uncarboxyolated Osteocalcin, Male, Hypogonadism
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