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KMID : 1039620180080010118
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Korean Journal of Family Practice
2018 Volume.8 No. 1 p.118 ~ p.124
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Obesity and the Risk of Dementia: A Meta-Analysis of Prospective Cohort Studies
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Park Su-Jung
Ko Hae-Jin
Youn Chang-Ho
Kim A-Sol
Moon Han-Na
Eun Hyo-Jeong
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Abstract
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Background: Obesity and dementia are important public health issues. Several studies have reported that obesity may increase the risk of dementia, but this has not reached a consistent conclusion. To evaluate the effect of obesity on the risk of dementia, we performed a meta-analysis of prospective cohort studies.
Methods: We systematically searched relevant studies on PubMed, Scopus, Cochrane Library, and CINAHL, which were published until November 2016. We selected prospective cohort studies about mid-life or late-life obesity and dementia based on predetermined inclusion criteria. The adjusted hazard ratio (HR) and 95% confidence interval (CI) were extracted from each study and analyzed using a random-effects model.
Results: A total of 12 studies were included in the final analysis. Compared to normal weight, mid-life or late-life obesity significantly increased the risk of dementia (HR 1.525, 95% CI 1.022?2.276; I2=93.108%, P＜0.001). In subgroup analysis, mid-life obesity increased the risk of dementia (HR 1.924, 95% CI 2.714?3.728), but late-life obesity did not show a significant result (HR 0.788, 95% CI 0.447?1.389). There were no significant differences in other subgroup analyses according to type of dementia and quality of studies. No apparent publication bias was found.
Conclusion: This study concludes that late-life and especially mid-life obesity is associated with the increased risk of dementia. It is important to control mid-life obesity to prevent late-life dementia.
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KEYWORD
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Overweight, Obesity, Dementia, Alzheimer Disease, Vascular Dementia
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