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KMID : 1039620180080010147
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Korean Journal of Family Practice
2018 Volume.8 No. 1 p.147 ~ p.150
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Do Benign Pancreatic Cysts Increase the Incidence Risk of Pancreatic Cancer?: For Korean Aged over 40 Years
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Kim Yong-Hwan
Kim Yong-Gwang
Jung Yo-Han
Shin Hyun-Gye
Kim Mi-Hye
Dong Jae-June
Shim Jae-Yong
Lee Duk-Chul
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Abstract
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Background: Whether pancreatic cysts such as mucinous cystic neoplasm and intraductal papillary mucinous neoplasm have malignant potential is known. However, whether patients with benign pancreatic cysts have a higher risk of pancreatic cancer (PaCa) has not been established yet.
Methods: We evaluated data from the National Health Insurance Service-National Sample Cohort (2002?2006) of the Korean National Health Insurance Service. Patients with pancreatic cysts detected on computed tomography/magnetic resonance imaging were identified using the Korean Classification of Diseases, 6th Edition. Patients aged >40 years with and those without pancreatic cystic lesions were followed up until 2010 (389,777 patients).
Results: During the study period, PaCa was diagnosed in 2 of 71 patients with pancreatic cysts and in 1,605 of 389,706 patients without pancreatic cyst. The incidence rates of PaCa were 2.82% and 0.41%, respectively. The hazard ratio of PaCa in all the patients with cysts was 9.839 (95% confidence interval, 2.461?39.332; P=0.0012) when compared with the rest of the patients without cysts.
Conclusion: Patients aged >40 years with pancreatic cysts have a significantly higher risk of PaCa.
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KEYWORD
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Pancreatic Cysts, Pancreatic Neoplasms, Incidence, Risk
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