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KMID : 1039620180080030435
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Korean Journal of Family Practice
2018 Volume.8 No. 3 p.435 ~ p.440
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The Relationship between Atherosclerosis Index and Vitamin D in Korean Male Adults
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Won Ji-Hye
Kim Kyu-Nam
Lee Seon-Yeong
Kim Dea-Youn
Shin Hye-Rin
Paek Jeong-Ki
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Abstract
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Background: Recently, interest in vitamin D has been increasing in the medical field. Vitamin D receptors have been found in various tissues such as muscles and endothelial cells of blood vessels, other than the musculoskeletal system. Studies on the relationship between vitamin D level and cardiovascular diseases have been actively conducted. We investigated the correlation between atherogenic index and vitamin D level in healthy Korean men.
Methods: The study included 438 male subjects whose ankle-brachial indexes and serum 25(OH)D levels were measured between January 2016 and December 2016 at the health promotion center of a Sanggye Paik Hospital. They were divided into deficient and sufficient groups according to a cutoff 25(OH)D level of 20 ng/mL. Age, smoking, hypertension, diabetes, and dyslipidemia were considered traditional risk factors of peripheral arterial disease, and ankle-brachial index was used as an atherogenic index.
Results: The ankle-brachial index was statistically significantly different between the two groups (1.11±0.006 vs. 1.14±0.005, P=0.001). Multivariate regression analysis revealed that vitamin D level (β=0.177) and smoking (β=-0.140) were independently associated with ankle-brachial index (P<0.05). We found a statistically significant positive correlation between vitamin D level and ankle-brachial index after adjusting for the traditional risk factors of peripheral arterial disease. However, these correlations were no longer statistically significant after the serum 25(OH)D concentration reached 25 ng/mL.
Conclusion: Primary prevention of peripheral arterial disease requires vitamin D supplementation, but excessive supplementation is unnecessary.
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KEYWORD
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Ankle-Brachial Index, Vitamin D, Age, Smoking, Fasting Blood Glucose, Inflammatory Marker
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