KMID : 1039620180080030462
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Korean Journal of Family Practice 2018 Volume.8 No. 3 p.462 ~ p.467
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Relationship between the Ratio of Triglyceride to High Density Lipoprotein and Glycated Hemoglobin A in 4-5 Years Follow-up in Non-Diabetic Adults
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Kim Hyun-Ha
Park Woo-Joo Jang Soo-Eun Yoo Seung-Ryoung Lee Hyeona-A Oh Mi-Kyeong
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Abstract
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Background: There is growing interest in factors that can predict the occurrence of diabetes. Several studies have reported that the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C ratio) reflects insulin resistance. The present study investigated whether the TG/HDL-C ratio can be a predictor of diabetes mellitus, considering that insulin resistance is an important mechanism for the risk of diabetes mellitus.
Methods: Among 1,177 patients who underwent two or more tests at 4- or 5-year intervals from 2006 to 2016 at a hospital health examination center in Gangwon-do Province, except for patients with chronic illnesses affecting the quality of data and lipid levels, 817 patients were included in the study. High TG/HDL-C ratios were based on previous studies: 3.5 for men and 2.0 for women. We investigated the relationship between the TG/HDL-C ratio and glycated hemoglobin A (HbA1c) levels, and we examined whether the first TG/HDL-C ratio was related to changes in HbA1c levels and the presence or absence of diabetes after 4?5 years.
Results: Simultaneously, the high TG/HDL-C ratio group had significantly higher mean HbA1c levels. In men, the high TG/HDL-C ratio group showed a tendency of increased HbA1c levels 4?5 years later (P=0.060). In logistic regression analysis, the TG/HDL-C ratio did not show a significant relationship with the incidence of diabetes after 4?5 years.
Conclusion: Although the TG/HDL-C ratio is closely related to HbA1c levels, this study did not predict the increase in HbA1c levels and the occurrence of diabetes after 4?5 years.
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KEYWORD
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Triglycerides, Lipoprotein HDL, Glycated Hemoglobin A , Diabetes Mellitus, Insulin Resistance
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