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KMID : 1039620180080030462
Korean Journal of Family Practice
2018 Volume.8 No. 3 p.462 ~ p.467
Relationship between the Ratio of Triglyceride to High Density Lipoprotein and Glycated Hemoglobin A in 4-5 Years Follow-up in Non-Diabetic Adults
Kim Hyun-Ha

Park Woo-Joo
Jang Soo-Eun
Yoo Seung-Ryoung
Lee Hyeona-A
Oh Mi-Kyeong
Abstract
Background: There is growing interest in factors that can predict the occurrence of diabetes. Several studies have reported that the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C ratio) reflects insulin resistance. The present study investigated whether the TG/HDL-C ratio can be a predictor of diabetes mellitus, considering that insulin resistance is an important mechanism for the risk of diabetes mellitus.

Methods: Among 1,177 patients who underwent two or more tests at 4- or 5-year intervals from 2006 to 2016 at a hospital health examination center in Gangwon-do Province, except for patients with chronic illnesses affecting the quality of data and lipid levels, 817 patients were included in the study. High TG/HDL-C ratios were based on previous studies: 3.5 for men and 2.0 for women. We investigated the relationship between the TG/HDL-C ratio and glycated hemoglobin A (HbA1c) levels, and we examined whether the first TG/HDL-C ratio was related to changes in HbA1c levels and the presence or absence of diabetes after 4?5 years.

Results: Simultaneously, the high TG/HDL-C ratio group had significantly higher mean HbA1c levels. In men, the high TG/HDL-C ratio group showed a tendency of increased HbA1c levels 4?5 years later (P=0.060). In logistic regression analysis, the TG/HDL-C ratio did not show a significant relationship with the incidence of diabetes after 4?5 years.

Conclusion: Although the TG/HDL-C ratio is closely related to HbA1c levels, this study did not predict the increase in HbA1c levels and the occurrence of diabetes after 4?5 years.
KEYWORD
Triglycerides, Lipoprotein HDL, Glycated Hemoglobin A , Diabetes Mellitus, Insulin Resistance
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