|
KMID : 1039620180080030477
|
|
Korean Journal of Family Practice
2018 Volume.8 No. 3 p.477 ~ p.481
|
|
|
Association of Metabolic Syndrome with White Matter Hyperintensity Volume in Neurologically Healthy Adults
|
|
Kang Mi-So
Park Jin-Ho
Nam Ki-Woong
Kwon Hyung-Min
Kim Sang-Hyuck
Jeong Su-Min
Kim Shin-Hye
Yoo Tae-Gon
Lee Ji-Eun
|
|
|
Abstract
|
|
|
Background: White matter hyperintensity (WMH), known to be caused by chronic ischemic damage in blood vessels, is a predictor of stroke and cognitive decline. Metabolic syndrome (MS) is a risk factor for blood vascular disorders, such as atherosclerosis. This study aimed to analyze the association of MS with WMH volume in adults without a history of stoke or transient ischemic attack.
Methods: A total of 3,168 subjects who underwent brain magnetic resonance imaging as part of a screening health check-up were enrolled in this study. WMH volume was quantitatively measured, and its square root value was calculated for the normal distribution data prior to analysis. MS was defined as according to the 2009 American Heart Association guidelines. Multivariate linear regression analysis was performed for the association between MS and WMH volume after adjustments for age, sex, body mass index, current smoking status, and anticoagulant or antithrombotic drug intake.
Results: The mean age of the subjects was 56.4±9.5 years, and the mean WMH volume was 2.6±6.3 cm3. A total of 849 subjects (26.8%) met the diagnostic criteria for MS. In multivariate linear regression analysis, MS showed a significant association with WMH volume (β=0.155; P<0.001), and WMH volume tended to increase with an increase in the number of MS components (P<0.001).
Conclusion: MS incidence and its severity, measured by the number of components, were independently associated with WMH volume. Longitudinal studies should be performed in future to evaluate their causal relationship and degree of association.
|
|
|
KEYWORD
|
|
|
Leukoaraiosis, Metabolic Syndrome, Magnetic Resonance Imaging, Cerebrovascular Diseases
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|