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KMID : 1039620180080050703
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Korean Journal of Family Practice
2018 Volume.8 No. 5 p.703 ~ p.708
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Risk Factors of Gallbladder Polyp, and Association between Gallbladder Polyp and Dyslipidemia in Health Examines
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Jung Kwang-Wook
Koh Ah-Ra
Kim Chun-Hwan
Bang Jun-Ho
Lee Jung-Hwan
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Abstract
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Background: Gallbladder polyps may be a cause of gallbladder cancer. The known risk factors for gallbladder polyps include male sex, obesity, metabolic syndrome, and hepatitis B surface antigen positivity. However, previous studies on the relationship between blood lipid levels and gallbladder polyps have been unclear. We evaluated risk factors for gallbladder polyps and the association between dyslipidemia and gallbladder polyps.
Methods: From January 2011 to December 2014, 6,865 individuals who visited a health checkup center, Dongsuwon Hospital in Suwon were examined for height, body weight, blood pressure, blood chemistry, and lipid profile. We also performed abdominal ultrasonography to identify gallbladder polyps. The risk factors for gallbladder polyps were analyzed by multivariate analysis.
Results: The prevalence of gallbladder polyps was 3.3% (227/6,865). There were more men and more obese patients (body max index ≥25 kg/m2) in the gallbladder polyp group than in the non-gallbladder polyp group. Moreover, height, body weight, total cholesterol, and low density lipoprotein (LDL) cholesterol were statistically higher in the gallbladder polyp group than in the non-gallbladder polyp group. In the multivariate analysis, male sex (odd ratio [OR] 2.198), obesity (OR 1.378), and LDL cholesterol (OR 1.007) were risk factors for gallbladder polyps. In the univariate analysis, patients with LDL cholesterol level ＞130 mg/dL had a 1.7-times (OR 1.778) higher risk of developing gallbladder polyps than those with LDL cholesterol level ＜130 mg/dL.
Conclusion: The risk factors for gallbladder polyps were male sex, obesity, and high LDL cholesterol. Triglyceride and high density cholesterol levels were not associated with the presence of gallbladder polyps.
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KEYWORD
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Gallbladder Disease, Hypercholesterolemia, Obesity, Male
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