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KMID : 1039620180080050709
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Korean Journal of Family Practice
2018 Volume.8 No. 5 p.709 ~ p.715
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Assessment of Association between Cognitive Impairment and Cardio-Cerebrovascular Disease
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Yun Jeong-Yeon
Wang Soo-Jin
Jang Mi-So
Jeong Su-Min
Kim Sang-Hyuck
Yoon Jae-Moon
Son Ki-Young
Cho Be-Long
Lee Ji-Eun
Shin Dong-Wook
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Abstract
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Background: Cardio-cerebrovascular disease is an important medical problem and is a leading cause of death worldwide. Since it shares a number of risk factors with cognitive impairment, it is necessary to confirm the relationship between the two diseases and to investigate the possibility of cognitive function as a predictive marker for cardio-cerebrovascular disease.
Methods: The study population included participants of the National Health Screening for People in a Transitional Period - 66 years old. Participants who did not answer all the 5 questions related to cognitive function and those who had experienced myocardial infarction or stroke before the day of screening were excluded. In all, 63,350 participants were included in the analysis. The risks of myocardial infarction and stroke occurrence according to the baseline cognitive function were assessed by Cox proportional hazards analysis. In addition, these factors were analyzed in a multivariable model including typical cardiovascular risk factors.
Results: The cognitive impairment group had higher risks of myocardial infarction (hazard ratio [HR] 1.99, 95% confidence interval [CI] 1.06?3.75) and stroke occurrence (HR 1.46, 95% CI 1.05?2.03) than the non-impairment group. The risks were also significantly higher according to the multivariable model including typical cardiovascular risk factors, namely sex, hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking (adjusted HR 2.12, 95% CI 1.13?4.01 for myocardial infarction, adjusted HR 1.45, 95% CI 1.04?2.01 for stroke).
Conclusion: The cognitive impairment group had a significantly higher risk of subsequent myocardial infarction and stroke occurrence than the non-impairment group. Thus, cognitive impairment may serve as a predictive marker for cardio-cerebrovascular disease.
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KEYWORD
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Cognitive Function, Prescreening Korean Dementia Screening Questionnaires, Cardiovascular Event, Stroke
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