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KMID : 1039620180080050764
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Korean Journal of Family Practice
2018 Volume.8 No. 5 p.764 ~ p.770
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A Cross-Sectional Study of the Association between Thyroid Hormones and Thyroid-Stimulating Hormone with Parameters of the Metabolic Syndrome in Korean Men and Women
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Oh Hye-Jin
Kim Moon-Hee
Kwon Yu-Ri
Kim Hye-Won
Kim Moon-Jong
Kim Young-Sang
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Abstract
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Background: The relationship between subclinical hypothyroidism and metabolic syndrome (MetS) is not clear. This study aimed to investigate the association between thyroid hormones and thyroid stimulating hormone with parameters of MetS in euthyroid and subclinical hypothyroid Korean individuals.
Methods: This cross-sectional study included 139 men and 127 women who participated in the medical examination program. Using multiple linear regression analysis, we evaluated the associations between thyroid hormones and thyroid stimulating hormone (TSH) with the parameters of MetS, respectively in men and women.
Results: Even after adjustment for age, body mass index, smoking, drinking, and exercise, we found no significant association between TSH and all parameters of MetS in both sexes. However, the association between not only free thyroxine (FT4) and total cholesterol but also free triiodothyronine (FT3) and diastolic BP in men was unaffected by adjustments made to age, body mass index, and lifestyle factors. In contrast, the FT4 level in women was not associated with MetS parameter while FT3 level was negatively associated with high-density lipoprotein (HDL)-cholesterol in women.
Conclusion: FT4 showed significant positive correlation with total cholesterol in men, and FT3 presented significant negative correlation with HDL-cholesterol in women. The findings suggest that when FT4 and FT3 levels are abnormal, it may be beneficial to check MetS parameters in Korean individuals.
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KEYWORD
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Metabolic Syndrome, Thyroid Hormones, Thyroid Stimulating Hormone, Total Cholesterol, High-Density Lipoprotein Cholesterol
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