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KMID : 1039620180080050771
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Korean Journal of Family Practice
2018 Volume.8 No. 5 p.771 ~ p.774
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Factors Associated with Neoplastic Transformation in Gastric Polyps
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Cheung Boo-Yoon
Chu Myeong-Su
Kim Ji-Hyun
Kang Chung
Kim Seung-Hee
Lee Su-Hwa
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Abstract
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Background: Risk factors for the development of stomach cancer include genetic or familial syndromes, gastric colonization by Helicobacter pylori, and conditions resulting in gastric dysplasia. However, risk factors for malignant transformation of benign gastric ulcers, fundic gland polyps, and the most common type, hyperplastic polyps (HPs), have not been fully revealed. The aim of this study was to identify the incidence of dysplasia and cancer associated with gastric HPs and the factors associated with their neoplastic transformation.
Methods: Between January 2010 and November 2016, data from 683 patients with gastric HPs who underwent endoscopic removal or surgical resection were analyzed retrospectively.
Results: Neoplastic transformation was found in 28 cases (4.1%) of 683 patients with gastric HPs including 4 (0.6%), 5 (0.7%), and 17 (2.5%) cases of low-grade dysplasia, high-grade dysplasia, and adenocarcinoma, respectively. Neoplastic transformations were significantly associated with polyps ＞2 cm in size (n=65 [9.5%] vs. n=618 [90.4%], P=0.049). However, no significant correlation was found between neoplastic transformation and age, sex, number of polyps detected per patient, location of polyps, or H. pylori infection.
Conclusion: Although the incidence of dysplasia and cancer in gastric HPs is still very low, malignant transformation of gastric HPs had a significant correlation with polyps ＞2 cm in size. Therefore, when gastric HPs larger than 2 cm are detected during screening, endoscopic polypectomy or surgical resection should be considered to reduce the risk of neoplastic transformation.
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KEYWORD
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Stomach, Cancer, Polyp, Dysplasia, Neoplastic, Transformation
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