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KMID : 1039620200100020110
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Korean Journal of Family Practice
2020 Volume.10 No. 2 p.110 ~ p.115
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The Association between Non-Alcoholic Fatty Liver Disease Fibrosis Score and Serum Low Density Lipoprotein-Cholesterol Levels in Adults with Non-Alcoholic Fatty Liver Disease
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Park Sang-Bong
Choi Hee-Jeong
Choi Hee-Jeong
Doo Song-Hee
Jung Dong
Shim Ye-Na
Oh Han-Jin
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Abstract
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Background: Non-alcoholic fatty liver disease fibrosis score (NFS) is a scoring system applied in clinical practice to predict advanced fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Evidence shows that progression of steatohepatitis and liver fibrosis reduces the production of very-low-density lipoprotein. The aim of this study was to identify the association of NFS and serum low-density lipoprotein cholesterol (LDL-C) levels and in adults with NAFLD.
Methods: Data were gathered from 24,889 subjects who had visited a health promotion center. NFS was calculated to assess the severity of fibrosis in all the subjects. Serum LDL-C levels were measured using a direct method.
Results: Serum LDL-C levels tended to decrease with increasing NFS quartiles (P for trend<0.01). NFS was one of the major determinants of serum LDL-C level after adjusting for age, sex, lifestyle-related factors, and other covariates. The estimated mean serum LDL-C level was significantly lower in the highest quartile of NFS than in the lowest quartile of NFS.
Conclusion: NFS had a negative association with serum LDL-C levels in adults with NAFLD. Elevated LDL-C level is not only a risk factor of cardiovascular disease but also a predictive indicator of NAFLD severity.
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KEYWORD
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Nonalcoholic Fatty Liver Disease, Cholesterol, LDL, Cholesterol, VLDL, Fibrosis
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