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KMID : 1129720000170010001
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Korean Journal of Acupuncture
2000 Volume.17 No. 1 p.1 ~ p.10
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Effects of Gamdutang Aqua-acupuncture Solution on Tumor Cell Lines in vitro
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Han Sang-Hoon
Park In-Kyu
Lim Chang-Soo
Moon Jin-Young
Lim Jong-Kook
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Abstract
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Gamdutang aqua-acupuncture solution(GAS) and Gamdutang water-extracted solution(GWS) were prepared and tested for potential antitumor activities. It was shown to possess considerable toxicity toward various tumor cell lines. Concentration of 5× and 10× of GAS resulted in more than 70% inhibition of growth in Ehrlich ascites tumor cells(EATC), hepa1c1c7 and A549. GAS at the concentration of 10× and 5× revealed that more than 60% inhibition in HeLa. GWS showed more than 50% inhibition of growth with EATC, HeLa at the concentration of 5× and 10×. Toxicity assay with GWS in hepa1c1c7 and A549 revealed that more than 80% inhibition of growth at the concentration of 5× and 10×. In morphological study, the number of cells were decreased, and the shape of cells was round-form. Most of cells is detached in EATC, Hepa1c1c7, HeLa, and A549 with GAS. These results suggest that GAS has antitumor activity in vitro.
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KEYWORD
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Gamdutang, EATC, Hepa1c1c7, A549, HeL, Antitumor
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