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KMID : 1129720000170010011
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Korean Journal of Acupuncture
2000 Volume.17 No. 1 p.11 ~ p.17
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Effect of Aqua-acupuncture Solution of Medicinal Plants on Induction of Anticarcinogenic PhaseⅡ Enzymes
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Lim Jong-Kook
Cho Kyoung-Hee
Nam Kyung-Soo
Shon Yun-Hee
Moon Jin-Young
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Abstract
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Induction of phase Ⅱ enzymes such as quinone reductase (QR) or glutathione S-transferase (GST) is considered a major mechanism of protection against initiation of carcingenesis. The induction of detoxification enzymes and glutathione were studied with Lonicerae Flos aqua-acupuncture solution (LFAS), Angelicae gigantis Radix aqua-acupuncture solution (AGRAS), and Gamdutang aqua-acupunture solution (GAS) in murine hepatoma cells grown in microtiter plate wells. LFAS, AGRAS and GAS were potent inducers of QR activity. LFAS was induced about 2.6-fold at concentration of 3×. AGRAS and GAS were also induced about 2.6-, 1.8-fold at concentration of 5×, respectively. In addition, GST activity was increased with LFAS, AGRAS, and GAS. GSH levels were increased about 2-fold with LFAS at concentration of 5×, 1.3-fold with AGRAS at concentration of 3×, and 1.2-fold with GAS at concentration of 5×. These results suggested that LFAS, AGRAS, and GAS may act as blocking agents against carcinogenesis by induction of phase Ⅱ marker enzymes.
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KEYWORD
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Phase Ⅱ detoxifying enzymes, Lonicerae Flos aqua-acupuncture solution (LFAS), Angelicae
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