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KMID : 1129720000170020069
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Korean Journal of Acupuncture
2000 Volume.17 No. 2 p.69 ~ p.76
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Immunohistochemical Study on Vasoactive Intestinal Polypeptide Containing Neurons in Cerebral Cortex of Sprague Dawley Fasted Rats Induced by Auricular Acupuncture
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Hwang Dae-Yeon
Kim Youn-Jung
Jang Mi-Hyun
Chung Joo-Ho
Kim Chang-Ju
Kim E-Hwa
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Abstract
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Stimulation of the auricle is known to be effective in reducing obesity. The aim of the present study is to investigate whether stimulating a specific auricular acupuncture point is effective on suppression of appetite. Vasoactive intestinal polypeptide (VIP) is known to induce a powerful feeding response after central administration and particularly abundant in the cerebral cortex. In food-deprived rats exhibiting a strong drive for feeding, decreased VIP release was markedly detected in the cerebral cortex of the brain. Needling the fasted rats on the specific auricular region increased the VIP level of the cerebral cortex. In conclusion, stimulating the specific auricular points increases VIP-expression in the cerebral cortex of the fasted rats and may be useful for controlling obesity.
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KEYWORD
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Auricular acupuncture, Vasoactive intestinal polypeptide, Food intake, Obesity, Neuropeptide
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