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KMID : 1129720010180010001
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Korean Journal of Acupuncture
2001 Volume.18 No. 1 p.1 ~ p.9
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Induction of Phase Ⅱ Enzyme Activity by Artemisia asiatica Nakai Aqua-acupuncture Solution
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Yoon Sung-Mook
Cho Kyoung-Hee
Shon Yun-Hee
Nam Kyung-Soo
Lim Jong-Kook
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Abstract
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Artemisia asiatica Nakai aqua-acupuncture solution (ANAS) was administered once daily for 10 days before the tumor implantation (1×106 cells). Body weight, spleen weight and the number of ascitic tumor cells were measured at 6 days after tumor implantation. The change of body weight and the survival rate of mice were observed for 21 days. It was used three biomarkers (quinone reductase, glutathione, glutathione S-transferase) to test chemopreventive potentials of ANAS. ANAS exerted antitumor activity by inhibiting the growth of Ehrlich ascites tumor cells in vivo. Mice given Ehrlich cells and ANAS at CV12 and BL18 had 57.1% to 42.9% survival after 21 days. Quinone reductase activity and glutathione levels were increased with ANAS. However, glutathione S-transferase level was 1.1-fold with ANAS. These results suggest that ANAS has chemopreventive potential by inducing QR activity and increasing GSH level.
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KEYWORD
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Artemisia asiatica Nakai aqua-acupuncture solution (ANAS), Quinone reductase, Glutathione, Glutathione S-transferase
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