KMID : 1129720010180010007
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Korean Journal of Acupuncture 2001 Volume.18 No. 1 p.7 ~ p.12
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Screening of Xanthium sibiricum Patr. Aqua-acupuncture Solution as the Cancer Chemopreventive Agent
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Lee Ki-Taek
Cho Kyoung-Hee Shon Yun-Hee Nam Kyung-Soo Lim Jong-Kook
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Abstract
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Xanthium sibiricum Patr. aqua-acupuncture solution (XPAS) and Xanthium sibiricum Patr. water-extracted solution (XPWS) were prepared and investigated for the potential of cancer chemoprevention. The following effects as chemopreventive agents were measured. : (a) Inhibition of DMBA-induced cytochrome P4501A1 activity (b) Inhibition of free radical formation in human leukemic cells. There was sligt inhibitory effect on the activity of cytochrome P4501A1 enzyme with the treatment of XPAS. Free radical formation was inhibited by 50.5% and 43.7% with XPAS at the concentration of 0.1¡¿, 0.5¡¿, respectively. These results suggest that XPAS has chemopreventive potential by inhibiting the activity of cytochrome P4501A1 and free radical formation.
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KEYWORD
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Xanthium sibiricum Patr., Cytochrome P4501A1 activity, Free radical formation
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