KMID : 1129720010180010021
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Korean Journal of Acupuncture 2001 Volume.18 No. 1 p.21 ~ p.26
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Induction of Glutathione S-transferase and NAD(P)H:Quinone Reductase by Astragali Radix Aqua-acupuncture Solution
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Ryu Jun-Seon
Lim Jong-Kook
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Abstract
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Induction of phase ¥± enzymes such as quinone reductase (QR) or glutathione S-transferase (GST) is considered a major mechanism of protection against initiation of carcingenesis. This study was desinged to investigate the potential of Astragali Radix Aqua-acupuncture Solution (ARAS) to induce phase ¥± enzymes and glutathione (GSH) in murine hepatoma cells grown in microtiter plate wells. ARAS was potent inducers of QR activity. ARAS was induced about 2.6-fold at concentration of 5¡¿. In addition, GST activity was increased with ARAS. GSH levels were increased about 1.2-fold with ARAS at concentration of 0.1¡¿. These results suggested that ARAS may act as blocking agents against carcinogenesis by induction of phase ¥± marker enzymes.
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KEYWORD
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Astragali Radix Aqua-acupuncture Solution (ARAS), Phase ¥± detoxifying enzymes
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