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KMID : 1129720010180010143
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Korean Journal of Acupuncture
2001 Volume.18 No. 1 p.143 ~ p.156
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Modulation of Cyclic AMP-PKA System on Inhibitory and Excitatory Herbs-induced Ion Currents
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Kim Youn-Jung
Shin Min-Chul
Chung Joo-Ho
Lee Choong-Yeol
Kim E-Hwa
Kim Chang-Ju
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Abstract
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Modulatory effect of cAMP-PKA system on inhibitory- and excitatory herbs-induced ion currents were investigated by nystatin-perforated patch clamp method under voltage-clamp condition. Ion currents induced by Bupleuri radix and Coptidis rhizoma were not affected by cAMP-PKA system. Ion current induced by Ecliptae herba was partially inhibited by cAMP-PKA system. Ion currents induced by Aconiti tuber and Boshniakiae herba were inhibitory modulated and ion current induced by Zingiberis rhizoma was excitatory modulated by cAMP-PKA system. Modulation of cAMP-PKA system on ion currents induced by Ginseng radix was fluctuated. In this results, it can be seen generally that excitatory herbs-induced ion currents were modulated by cAMP-PKA system while cAMP-PKA system did not affect inhibitory herbs-induced ion currents.
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KEYWORD
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Cyclic AMP, PKA, Excitatory herbs, Inhibitory herbs, Patch clamp
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