KMID : 1129720010180020001
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Korean Journal of Acupuncture 2001 Volume.18 No. 2 p.1 ~ p.6
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Effect of Astragali Radix Aqua-acupuncture Solution on the Initiation Carcinogenesis
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Ryu Jun-Seon
Cho Kyoung-Hee Shon Yun-Hee Nam Kyung-Soo Lim Jong-Kook
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Abstract
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The effects of Astragali radix aqua-acupuncture solution (ARAS) and Astragali radix water-extraced solution (ARWS) on the phase¥° enzyme and carcinogen-DNA adduct formation were examined. There were 11.3% and 13.4% inhibition in the activity of cytochrome P4501A1 enzyme with the treatment 3¡¿ and 5¡¿ of ARAS, respectively. At concentration of 0.1¡¿ and 1¡¿ ARAS, the binding of [3H]B[a]P metabolites to DNA of NCTC-clone 1469 cell was inhibited by 6.9%, 29.3%, respectively. These results suggest that ARAS has chemopreventive potential by inhibiting cytochrome P4501A1 activity and benzo[a]pyrene-DNA adduct formation.
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KEYWORD
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Astragali radix, Cytochrome P4501A1 enzyme, Carcinogen-DNA adduct
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