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KMID : 1129720010180020047
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Korean Journal of Acupuncture
2001 Volume.18 No. 2 p.47 ~ p.56
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Effect of Citri Reticulatae Viride Pericarpium on the Cerebral Blood Flow and Peritoneal Macrophages
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Kim Nam-Sun
Hwang Kyung-Taek
Hwang Il-Taek
Kand Duk-Soo
Kang Hak-Chun
Han Jong-Hyun
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Abstract
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Citri Reticulatae Viride Pericarpium is being used to regulate the flow of gi. However, the mechanism of its pharmacological actions is not well understood. The purpose of this research was to investigate effects of Citri Reticulatae Viride Pericarpium on peritoneal macrophages in mice and blood pressure, regional cerebral blood flow in rats. Nitric oxide production was tested using a Griess reagents, and a phagocytic activity of mouse peritoneal macrophage was tested using a luminometer. Blood pressure and regional cerebral blood flow was tested using a phygiograph, MacLab and Macintosh computer with data acquisition system. 1.Blood pressure was increased by Citri Reticulatae Viride Pericarpium in a dose-dependent manner. 2. rCBF was increased by Citri Reticulatae Viride Pericarpium in a dose-dependent manner. 3. Pretreatment with propranolol significantly inhibited Citri Reticulatae Viride Pericarpium induced increase in rCBF. 4.Citri Reticulatae Viride Pericarpium inhibited nitric oxide production from peritoneal macrophages in mice. 5.Citri Reticulatae Viride Pericarpium accelerated phagocytic activity of peritoneal macrophage in mice.
These results suggest that Citri Reticulatae Viride Pericarpium causes a diverse response of blood pressure, regional cerebral blood flow(rCBF), nitric oxide production and phagocytic activity. The increase in rCBF is also mediated by adrenergic βrecepter.
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KEYWORD
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Citri Reticulatae Viride Pericarpium, Regional cerebral blood flow, Nitric oxide production and phagocytic activity
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