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KMID : 1129720010180020101
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Korean Journal of Acupuncture
2001 Volume.18 No. 2 p.101 ~ p.111
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Effect of Radix Glycyrrhizae on the Melanogenesis of Melanoma Cell Line
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Park Ji-Sun
Park Rae-Gil
Kim Jeong-Joong
Lee Hwang-Hee
Lim Jong-Kook
Jeong Seung-Il
Na Kyung-Sang
Han Jong-Hyun
Jeon Byung-Hoon
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Abstract
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To investigate whether glycyrrhizae inhibits melanogenesis, we utilized B16 melanoma cells. Glycyrrhizae alone decreased the tyrosinase promoter activity of B16 melanoma cells in dose-dependent manner. Glycyrrhizae attenuated tyrosinase promoter activity and tyrosinase activity. Glycyrrhizae also prevents phosphotransferase activity of c-Jun N-termianl kinase(JNK1) and transcriptional activation of AP-1 in α-MSH-treated B16 melanoma cells. In conclusion, the current studies for the first time demonstrated that an inhibitory effect of melanogenesis by glycyrrhizae on B16 mouse melanoma cell might be a new mechanism which down-regulates JNK activity via inhibition of AP-1 activity.
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KEYWORD
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Glycyrrhizae, Melanogenesis, α-MSH, JNK1, AP-1
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