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KMID : 1129720020190010007
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Korean Journal of Acupuncture
2002 Volume.19 No. 1 p.7 ~ p.13
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Effect of Cnidium officinale Makino Aqua-acupuncture Solution on Carcinogen-induced Carcinogenesis in In vitro
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Han Sang-Hoon
No Dong-Il
Lee Ki-Taek
Shon Yun-Hee
Baek Tae-Seon
Nam Kyung-Soo
Lim Jong-Kook
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Abstract
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The effects of Cnidium officinale Makino aqua-acupuncture solution (COMAS) and Cnidium officinale Makino water-extraced solution (COMWS) on the CYP1A1 activity and benzo[a]pyrene(B[a]P)-DNA adduct formation were examined. There were 6.8%, 12.1%, 15.1%, 18.3% and 22.6% inhibition in the activity of cytochrome P4501A1 enzyme with the treatment of 0.1×, 0.5×, 1×, 3× and 5× COMAS, respectively. At concentration of 0.1× COMAS, the binding of [3H]B[a]P metabolites to DNA of NCTC-clone 1469 cell was significantly inhibited by 56.9%. These results suggest that COMAS has chemopreventive potential by inhibiting cytochrome P4501A1 activity and benzo[a]pyrene-DNA adduct formation.
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KEYWORD
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Cnidium officinale Makino, cytochrome P4501A1 enzyme, benzo[a]pyrene-DNA adduct
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