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KMID : 1129720020190010035
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Korean Journal of Acupuncture
2002 Volume.19 No. 1 p.35 ~ p.45
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Effects of Electroacupuncture of GB30 on Transient Forebrain Ischemia Injury in Rats
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Kim Pung-Sik
Kim Jae-Hyo
Choi Dong-Ok
Kim Kyung-Sik
Sohn In-Chul
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Abstract
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Acupuncture and herbal medicine have been used to prevent and treat the cerebrovascular accident, such as a stroke, and many studies of acupuncture and moxibustion concerning to the stroke have been undertaken in the human and various animals. However, it was not published the protective effect of the electroacupuncture (EA) of Huan-do (GB30) on the transient forebrain ischemia injury. The neuroprotective effects of EA (2 ms, 10 Hz, and 1 - 2 mA) of GB30 on the transient forebrain ischemia injury was investigated by western blot of nNOS and hematoxylin and eosin stain in Sprague-Dawley rats. The transient forebrain ischemia injury resulted in increased expression of nNOS in the brain for 6 hrs after ischemia, and EA decreased significantly expression of nNOS protein in brain increased by transient forebrain ischemia injury. The survived neuronal cell stained with hematoxylin and eosin (H&E) decreased in the hippocampus by the 7 days after ischemia comparing with the normal. Comparing with the normal, the survived neurons seriously decreased cell in the hippocampus after the injury. However, the proportion of survived neurons was increased in EA treatment.
These results suggest that EA of GB30 have neuroprotective effects on transient forebrain ischemia injury.
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KEYWORD
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transient forebrain ischemia, electroacupuncture, GB30, nNOS, hematoxylin and eosin
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