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KMID : 1129720020190010069
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Korean Journal of Acupuncture
2002 Volume.19 No. 1 p.69 ~ p.77
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Anti-anemic Effect of Aqueous Extracts of Fructus schisandrae on Phenylhydrazine-induced Hemolytic Anemia in Female Sprague-Dawley Rats
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Shin Hye-Sook
Kim E-Hwa
Kim Chang-Ju
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Abstract
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Among the diseases common in women, anemia is the most commonly encountered. In general, anemia is defined as a condition in which the red blood cell count, hematocrit ratio and hemoglobin content of the circulating blood falls below normal. Because the normal range for many hematologic parameters are not defined, adult women with blood hemoglobin content of 12 gm/㎗ or lower are classified as being anemic in accordance with WHO criteria. Treatment and prevention of anemia in women are important because the occurrence of this disease is relatively higher in women than in men due not only to their monthly menstruation but also to pregnancy and parturition. Medical therapy is the most common way of controlling and managing anemia. Taking iron supplement pills is recommended for women, especially those who are pregnant. However, these iron supplements are known to cause irritation of the stomach and the intestines, constipation, and digestive troubles. For this reason, it has become necessary to develop new drugs for prevention and treatment of anemia with minimal side effects. Fructus schisandrae, also classified as Schisandrae chinensis Baill, is a well-known Oriental herb. It is widely encountered in everyday life, not only as materia medica but also in tea, food, and beverages. Fructus schisandrae is a major astringent, with a sour taste, and consists of organic acids including citric acid, tartaric acid, protocatechuic acid, and ascorbic acid. It has been reported that Fructus schisandrae is effective against virus- and chemical-induced hepatitis1-4). A synthetic schisandrin analogue, dimethyl dicarboxylate biphenyl (DDB), is now widely used as a hepato-protective drug, with high effectiveness in normalizing liver functions and very few side effects5-7); the protective effects of Fructus schisandrae against damage due to physical injury in rats and cyclohexamide-induced amnesia have also been reported8,9). However, the effect of Fructus schisandrae on hemolytic anemia has not been reported yet. In the present study, the anti-anemic effect of Fructus schisandrae on phenylhydrazine-induced hemolytic anemia in female Sprague-Dawley rats was investigated.
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KEYWORD
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Fructus schisandrae, Hemolytic anemia, Phenylhydrazine
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