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KMID : 1129720020190020025
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Korean Journal of Acupuncture
2002 Volume.19 No. 2 p.25 ~ p.33
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Effect of Acupuncture(HT7) on Acute Cocaine-induced locomotor Activity and Fos-like Immunoreactivity in the Brain of the Rats
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Lee Bom-Bee
Shim In-Sop
Yang Chae-Ha
Lee Hak-In
Hahm Dae-Hyun
Lee Hye-Jung
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Abstract
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Substantial evidence suggests that behavioral and reinforcing effects of cocaine can be mediated by the mesolimbic dopaminergic system. Injections of cocaine can produce one of the immediate-early gene, c-fos expression in the brain and behavioral activation. Acupuncture as a therapeutic intervention is widely used for the treatment of many mental disorders such as drugs of abuse. In order to investigate whether acupuncture has an influence on cocaine-induced reinforcing and behavioral effects, we examined the effect of acupuncture on cocaine-induced locomotor activity and c-Fos expression in the nucleus accumbens and the striatum using Fos-like-immunoreactivity(FLI). Male SD rats received acupuncture for 1 min after injection of cocaine hydrochloride(1 mg/kg, i.v.). The employed acupuncture point, Shenmen(HT7), has been clinically used to treat mental and psychosomatic disorders. Injections of cocaine produced a marked increase in locomotor activity and FLI in the nucleus accumbens and the striatum. Acupuncture at HT7, but not at control points(PC6, TE4 or tail), significantly attenuated cocaine-induced increase in locomotor activity and Fos-like immunoreactivity. These results demonstrated that reduction in locomotor activity by acupuncture may be reflected by reduction of postsynaptic neuronal activity in the nucleus accumbens and the striatum. Our results suggest that acupuncture may have a therapeutic effect on cocaine addiction.
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KEYWORD
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cocaine, acupuncture, locomotor activity, c-Fos, dopamine
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