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KMID : 1129720020190020051
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Korean Journal of Acupuncture
2002 Volume.19 No. 2 p.51 ~ p.56
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No Dong-Il
Lim Jong-Kook
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Abstract
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Induction of phase Ⅱ enzymes such as quinone reductase (QR) and glutathione S-transferase (GST) is considered a major mechanism of protection against initiation of carcinogenesis. The present study was performed to evaluate the chemopreventive activity of Acori Graminei Rhizoma aqua-acupuncture solution (AGRAS) and Acori Graminei Rhizoma water-extracted solution (AGRWS) by measuring the induction of phase II enzymes. AGRAS and AGRWS are potent inducers of quinone reductase activity in murine hepatoma Hepa1c1c7 cells. The levels of GSH and GST was increased sightly with AGRAS and AGRWS. These results suggest that AGRAS and AGRWS may act as blocking agents against carcinogenesis by induction of phase Ⅱ enzymes.
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KEYWORD
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Acori Graminei Rhizoma, phase Ⅱ enzyme, Quinone Reductase, Glutathione S-transferase,
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