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KMID : 1129720020190020057
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Korean Journal of Acupuncture
2002 Volume.19 No. 2 p.57 ~ p.61
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Effects of Cnidium officinale Makino Aqua-acupunture Solution on the Activity of Cytochrome P450 Enzyme in Mice
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Han Sang-Hoon
Shon Yun-Hee
Nam Kyung-Soo
Lim Jong-Kook
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Abstract
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The activities of phase I enzymes in the liver of mice were examined following the intragastric application of Cnidium officinale Makino aqua-acupunture solution (COMAS). Treatment of mice with COMAS resulted in decreases of cytochrome P450 1A1-dependent ethoxyresorufin-O-deethylation and cytochrome P450 2E1-dependent p-nitrophenol and aniline hydroxylation activities. These findings suggest that COMAS has chemopreventive potential by inhibiting cytochrome P450 1A1 and cytochrome P450 2E1 activities in mice.
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KEYWORD
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Cnidium officinale Makino, cytochrome P450 1A1, cytochrome P450 2E1
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