|
KMID : 1129720030200030061
|
|
Korean Journal of Acupuncture
2003 Volume.20 No. 3 p.61 ~ p.80
|
|
|
Effects of Folium Artemisiae Argyi and Moxa Tar’ Herbal Acupuncture on Transient Forebrain Ischemic Injury in Rats
|
|
Kim Jae-Hyo
Yi Kwan-Hyung
Ahn Young-Nam
Kim Yong-Deuk
Kim Kyung-Sik
Sohn In-Chul
|
|
|
Abstract
|
|
|
Objectives: Acupuncture and herbal medicine have been used to prevent and treat the cerebrovascular accident, such as a stroke, and many studies of acupuncture and moxibustion concerning to the stroke have been undertaken in the human and various animals. Recently, the new therapeutic tool, that is herbal acupuncture, has been developed since the 1950’ and applied to various diseases including the cerebrovascular accident. The main characteristics of herbal acupuncture are a combination of acupuncture and herbal medicine. It was not well known the therapeutic effect and the mechanism of herbal acupuncture on transient forebrain ischemic injury, although it has been used frequently in clinics.
Methods: In this study, effects of folium Artemisiae Argyi and moxa tar’ herbal acupuncture on the GV20, named Baek-Hue, on neuroprotection after the transient forebrain ischemia were investigated in Sprague-Dawely rats. Expressions of cFos, FosB and BDNF protein in the hippocampus and cortex were observed at 2 hrs and 48 hrs after transient forebrain ischemia by immunohis- tochemistry and ELISA technique.
Results: Expression of cFos protein was increased slightly in the hippocampus and cortex at 2 hrs after transient forebrain ischemia, but FosB protein was increased highly comparing to cFos protein. However, pretreatment with folium Artemisiae Argyi or moxa tar’ herbal acupuncture on GV20 significantly increased expression of cFos protein and significantly decreased expression of FosB protein compared to control group, respectively. These features were observed in the motor cortex and retrosplenial granular cortex as well as the hippocampus. Also, pretreatment with folium Artemisiae Argyi and moxa tar’ herbal acupuncture on GV20 significantly increased the expression of BDNF protein in the hippocampus and the cortex compared to control group at 48 hrs after transient forebrain ischemia, respectively.
Conclusions: These results suggest that pretreatment with folium Artemisiae Argyi or moxa tar’ herbal acupuncture on GV20 has neuroprotective effect on transient forebrain ischemia and theherbal acupuncture on GV20 may be related to antioxidative function.
|
|
|
KEYWORD
|
|
|
folium Artemisiae Argyi, transient forebrain ischemia, GV20, immediate early gene, BDNF
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|