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KMID : 1129720040210010015
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Korean Journal of Acupuncture
2004 Volume.21 No. 1 p.15 ~ p.27
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Effects of FOLIUM ARTEMISIAE ARGYI’ Herbal Acupuncture on the Expression of nNOS protein Following Transient Forebrain Ischemic Injury in Rats
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Choi Yun-Young
Kim Jae-Hyo
Jeon Moon-Kee
Lim Joung-Ah
Kim Kyung-Sik
Sohn In-Chul
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Abstract
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Objectives : Acupuncture has been used to prevent and treat the cerebrovascular accident, such as a stroke, and many studies of acupuncture and moxibustion concerning to the stroke have been undertaken in the human and various animals. Also, herbal acupuncture, namely aqua acupuncture has been applied and developed to various diseases including the cerebrovascular accident. FOLIUM ARTEMISIAE ARGYI is the dry leaf of Artemisia argyi Levl. et Vant. collected in summer before the plant blooms and used to moxibustion and has been recommended for use as an analgesic and hemostatic. In this study, effects of FOLIUM ARTEMISIAE ARGYI (艾葉)’ herbal acupuncture on the LR3, namely Taechung on neuroprotection after the transient forebrain ischemia were investigated in Sprague-Dawely rats.
Methods : Expressions of neuronal nitric oxide synthase (nNOS) protein in the hippocampus and cortex were observed at 2 hrs after transient forebrain ischemia by immunohistochemistry.
Results : Expression of nNOS protein was increased in the hippocampus and cortex at 2 hrs after transient forebrain ischemia. However, pretreatment with FOLIUM ARTEMISIAE ARGYI’ herbal acupuncture on LR3 significantly decreased expression of nNOS protein protein compared to ischemia group. These features were observed in the motor cortex and the hippocampus.
Conclusions : These results suggest that pretreatment with FOLIUM ARTEMISIAE ARGYI’ herbal acupuncture on LR3 inhibits the expression of nNOS protein induced by transient forebrain ischemia and may modulate excitatory toxicity of neuron related to neuronal cell death.
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KEYWORD
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FOLIUM ARTEMISIAE ARGYI, herbal acupuncture, cerebrovascular accident, nNOS
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