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KMID : 1129720040210010041
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Korean Journal of Acupuncture
2004 Volume.21 No. 1 p.41 ~ p.50
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The association of genetic polymorphism between responder and nonresponder to acupuncture in smoking cessation
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Yoon Dong-Hak
Park Hi-Joon
Kim Seung-Tae
Jin Soo-Hee
Lee Su-Jin
Lee Hye-Jung
Lim Sabina
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Abstract
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Objectives : This study was designed to investigate the differences of effects in smoking cessation after acupuncture treatment and we hypothesized that the discrepancies might be caused by individual genetic differences.
Methods : Acupuncture treatment was given to the subjects three times a week for the 231 healthy male Korean smokers without personal or familial history of psychiatric or neurological illness. We evaluated for differentiate responder and non-responder who showed more than 50% decrease in the cigarette consumption or the desire for smoking were regarded as responder, and less than 25% decrease in the cigarette consumption or the desire for smoking were regarded as non-responder, respectively. Allele and genotype frequencies of the Taq1 A polymorphism of dopamine D2 receptor (DRD2) gene were compared in 231male smokers. Chai-square analyses were performed to test for an interactive effect between the DRD2 Taq1 A allele.
Results : The allele frequencies and genotype distributions of DRD2 gene among the smokers (n = 231) showed significant the differences in their genotype distributions. The responder and non-responder showed the difference in genotype distribution with a prevalence of A1 allele. A slightly positive association of DRD2 Taq1 A1 genotypes with smoking was observed.
Conclusions : This experiment results indicate that the present of DRD2 allele genotype showing significant difference in the genotype distributions between responders and non-responders could be explained by the difference in the genetic effect of DRD2 A1 allele.
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KEYWORD
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Smoking cessation, Auricular acupuncture, Dopamine D2 receptor, Genetic polymorphism, Responder
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