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KMID : 1129720040210010079
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Korean Journal of Acupuncture
2004 Volume.21 No. 1 p.79 ~ p.93
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Influence on the Anti-cancer and Immune response improvement of Herbal-acupuncture with Sinomenii acuti Lignum infusion solution into Joksamni(ST36)
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Kim Tae-Han
Kim Young-Il
Hong Kwon-Eui
Yim Yun-Kyoung
Lee Hyun
Lee Byung-Ryul
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Abstract
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Objectives and methods : To study on the anti-cancer, anti-metastasis and immune response improvement effects of Herbal-acupuncture with Sinomenii acuti Lignum infusion solution(SAL-HAS), we injected Sinomenii acuti Lignum infusion solution into Joksamni(ST36) of C57BL/6 mouse which is corresponding to human Joksamni(ST36). We observed its effect on the number of CD25+/CD4+, CD8+/CD3e+, CD69+/B220+, NK1.1+/CD3e+ cells in mouse PBMCs(peripheral blood mononuclear cells), the number of the pulmonary colony , and the effect on MST(mean survival time) and ILS(increase in MST over control) of C57BL/6 mice implanted intravenously with B16-F10 melanoma.
Results and Conclusions : 1. The spleen cells proliferation of the sample groups treated with SAL-HAS extract has increased significantly compared with that of the control group. 2. The percentage of the CD25+/CD4+, CD8+/CD3e+, CD69+/B220+, NK1.1+/CD3e+ cells in C57BL/6 mouse PBMCs of the sample groups treated with SAL-HAS has increased compared with that of the control group. 3. The pulmonary colony number of the sample groups SAL-HAS has decreased significantly compared with that of the control group. 4. MST and ILS of the sample groups SAL-HAS have increased significantly compared with those of the control group.
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KEYWORD
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Sinomenii acuti Lignum(SAL), Herbal-Acupuncture, Joksamni (ST36), Anti-cancer, Immune response improvement
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