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KMID : 1129720040210020095
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Korean Journal of Acupuncture
2004 Volume.21 No. 2 p.95 ~ p.110
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Effects of Rhizoma Coptidis Herbal Acupuncture applied to HapGok (LI4) on TNBS-induced Colitis in rats
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Do Jin-Woo
Ahn Seong-Hun
Koo Sung-Tae
Baek Tae-Bong
Kim Kyung-Sik
Sohn In-Chul
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Abstract
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Objectives : Ulcerative colitis and Crohn’s diseases are chronic inflammatory disease of the gastrointestinal tract identified mainly for diarrhea, stomachache, hemafecia. The source and pathologic mechanism about ulcerative colitis and Crohn’s disease are still unknown but stress, infection, a genetic factor, environmental factors etc. may be the cause of chronic inflammatory disease of the gastrointestinal tract recently.
Methods : Because ulcerative colitis and Crohn’s disease is recognized as Ha-ri(下痢) or Jang-Byok(腸?) in Oriental Medicine, Rhizoma Coptidis Herbal acupunctures were injected in hapgok (LI4) which is used to treat intestinal disease in clinic. All animals were subjected to the injection of saline (300 ㎕, 500 ㎕) for a study control and TNBS (300 ㎕, 500 ㎕) into the lumen of the colon, 8cm proximal to the anus through the intestine. Rhizoma Coptidis Herbal (20 ㎎/㎖, 0.4 ㎖) acupuncture solution was injected to the LI4 (both hands) at the secondary injection time of TNBS in rats. And body weight, RBC count, WBC count, total protein, Paw edema rate, rate of protein leakage into CMC-pouch fluid, IgG levels and IgM levels were observed to study the effects of Rhizoma Coptidis Herbal acupuncture in hapgok (LI4).
Results : In results, Rhizoma Coptidis Herbal acupuncture in hapgok (LI4) on TNBS-induced colitis reduced the rate of weight loss but had no effect on RBC and WBC count. And it reduced total protein concentration, paw edema, rate of protein leakage into CMC-pouch fluid, IgG levels and IgM levels.
Conclusion : Data suggest that injection of Rhizoma Coptidis herbal acupuncture solution into hapgok has significant therapeutic effect on the colitis.
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KEYWORD
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Hapgok (LI4), Rhizoma Coptidis, Herbal acupuncture, Colitis
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