KMID : 1129720040210020111
|
|
Korean Journal of Acupuncture 2004 Volume.21 No. 2 p.111 ~ p.123
|
|
Effects of Cordyceps militaris Mycelia(CMM) herbal acupuncture at BL13, LU4 on airway smooth muscle, airway inflammation, IgE and Interleukin-4 in mouse model of allergic bronchial asthma
|
|
Youn Dae-Hwan
Choi Gwan-Jin Chae Woo-Seok Na Chang-Su
|
|
Abstract
|
|
|
Objectives : It has been reported that Cordyceps militaris Mycelia(CMM) has an effect on deficiency allergic asthma(úÈô·) clinically. The aim of this study was to determine an appropriate oriental treatment and the doses of CMM to treat asthma.
Methods : In order to study the effect of herbal acupuncture solution of the CMM on allergic asthma, the mouse were pretreated by CMM herbal acupuncture at BL13, LU4 before antigen sensitization. 2 days later Mice were actively sensitized with a subcutaneous injection of ovalbumin(OA) and 13 days later they were provoked with OA aerosols. IL-4, lymphocyte, macrophage in bronchoalveolar lavage fluid(BALF), IgE in serum, WBC, RBC, HGB in blood, and in vitro isometric contractile responses of the isolated tracheal smooth muscle(TSM) to acetylcholine(ACh, 0.1-1000 ¥ìM), KCl were measured.
Results : Contractile responses of TSM to ACh were significantly increased in CMM herbal acupuncture 1 group (Ach 1000 ¥ìM), CMM herbal acupuncture 2 group (ACh 1, 10 ¥ìM), CMM herbal acupuncture 3 group (Ach 0.3, 1, 30, 300 ¥ìM). The sensitivity of TSM to ACh was significantly decreased in CMM herbal acupuncture 3 group. The maximal contractile response of TSM to ACh was significantly decreased in CMM herbal acupuncture 1, 3 group. The maximal contractile response of TSM to KCl was significantly decreased in CMM herbal acupuncture 1, 2, 3 group. The counts of lymphocytes in BALF was significantly increased in CMM herbal acupuncture 3 group. The counts of macrophages in BALF was significantly decreased in CMM herbal acupuncture 3 group. Interleukin-4 level in BALF was significantly increased in CMM herbal acupuncture 1,3 group. and it was increased in CMM herbal acupuncture 2 group, but there was no significance. Serum IgE level was significantly decreased in CMM herbal acupuncture 1, 2, 3 group. The counts of WBC in blood was significantly increased in CMM herbal acupuncture 1, 3 group
Conclusion : Based on the above results it is assumed that CMM herbal acupuncture at BL13, LU4 can help the treatment of deficiency allergic Asthma
|
|
KEYWORD
|
|
allergic bronchial asthma, ordyceps militaris Mycelia(CMM), herbal acupuncture, airway inflammation, IgE, Interleukin-4
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|