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KMID : 1129720040210020139
Korean Journal of Acupuncture
2004 Volume.21 No. 2 p.139 ~ p.145
Inhibitory Effect of Lentinus edodes Aqua-acupuncture Solution on the Cytochrome P450 1A1 and 1A2 Activities.
Moon Jin-Young

Abstract
Objectives : Inhibition of phase I enzymes such as cytochrome P450 (CYP) 1A1 or 1A2 is considered a major mechanism of protection against initiation of carcinogenesis. The inhibition of toxic enzymes and CYP were studied with so many oriental herbral medicine. Recently, numerous polysaccharides and polysaccharide-protein complexes have been isolated from mushrooms and used as a source of therapeutic agents. The most promising biopharmacological activities of these polymers are their immunomodulation and anti cancer. But, in this study the inhibitory effect was on the aqua-acupuncture of Lentinus edodes.

Materials : Lentinus edodes aqua-acupuncture solution (LEAS) was prepared and tested for the inhibition of cytochrome P450 (CYP) 1A1 and 1A2 activities. LEAS type I from fruit body of these mushrooms. Type II was extracted from cultured broth of Lentinus edodes mycelum.

Results : LEAS type I and type II were significantly inhibited CYP 1A1 and 1A2 enzymes at concentration of 5.0 and 10.0 §·/§¢.

Conclusion : These results suggested that LEAS may act as block agent against carcinogenesis by inhibition of phase I enzymes.
KEYWORD
Lentinus edodes aqua-acupuncture solution (LEAS), Cytochrome P450 (CYP)
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