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KMID : 1129720040210030089
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Korean Journal of Acupuncture
2004 Volume.21 No. 3 p.89 ~ p.96
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The Protective Effect of Phospholipase Herbal-acupuncture against the Neuronal Damage Induced by Middle Cerebral Artery Occulsion(MCAO) in Rats
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Kim Sung-Min
Jung Tae-Young
Lim Seong-Chul
Seo Jung-Chul
Kim Mi-Ryeo
Yang Chae-Ha
Han Sang-Won
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Abstract
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Objectives : In order to prove the effect of Phospholipase Herbal-acupuncture, this experimental studies were performed by using rats that had neuronal damage due to the Middle Cerebral Artery Occulsion(MCAO).
Methods Microdialysis probes were implanted into the coordinate of striatum of anesthetized rats which consist of sham-operated 8 rats, MCAO-operated 8 rats and Herbal-acupuncture administrated 8 rats before MCAO operating. The Herbal-acupuncture(0.5mg/kg) was administrated to rats 30 minutes before having an operation causing the MCAO. The surgical excision lead the cross resected brain to the acute ischemic state. The brain was sliced in 2mm thickness and stained with cresyl violet buffer for the measurement of cerebral infarcted area and volume.
Results : Based on the result of the tissue inspection for the cerebral ischemic cell, Herbal-acupuncture significantly protect neurocytes.
Conclusions : We suggest Herbal-acupuncture produces protective effects against the neuronal damage induced by MCAO. Therefore, Herbal-acupuncture may prevent delayed neuronal death(DND) in selectively vulnerable focal areas of the brain effectively.
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KEYWORD
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Phospholipase, Herbal-acupuncture, Middle Cerebral Artery Occulsion(MCAO), Neuronal Damage
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